Evidence map›Paper›PMID 42113450›Full record

ArticleScience China. Life sciences2026

Human MAITregs possess diverse TCR repertoires and are functionally supported by glycolysis.

Maoyu Tang, Xinying Li, Xudong Yang, Changfeng Zhao, Yuwei Zhang, Sanwei Chen, Zhenghui Ye, Liujin Hou, Yusheng Chen, Rong Lv and 5 more

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maoyu TangSchool of Basic Medical Sciences, Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230032, China.
Xinying LiSchool of Life Sciences, Anhui Medical University, Hefei, 230032, China.
Xudong YangDepartment of Physical Education, University of Science and Technology of China, Hefei, 230027, China.
Changfeng ZhaoNational Key Laboratory of Immune Response and Immunotherapy, Department of Health Management Center of the First Affiliated Hospital, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Yuwei ZhangNational Key Laboratory of Immune Response and Immunotherapy, Department of Health Management Center of the First Affiliated Hospital, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Sanwei ChenDepartment of General Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Zhenghui YeDepartment of Hepatobiliary-Pancreatic Surgery and Organ Transplantation Center, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Liujin HouDepartment of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Yusheng ChenInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, 230601, China.
Rong LvAnhui Blood Center, Hefei, 230001, China.
Hongchuan ZhaoDepartment of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Xiaowen ChengDepartment of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Hua WangDepartment of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Li BaiSchool of Basic Medical Sciences, Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230032, China. baili@ustc.edu.cn.
Sicheng FuNational Key Laboratory of Immune Response and Immunotherapy, Department of Health Management Center of the First Affiliated Hospital, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. fsc@ustc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) regulatory cells (MAITregs) represent a specialized subset with immunosuppressive functions, yet their properties and molecular basis are largely unknown. We demonstrate that MAITregs, while sharing T cell receptor (TCR) repertoires with conventional MAIT cells, undergo selective clonal expansion during in vitro generation, leading to biased V(D)J profiles and restricted CDR3 diversity. Moreover, integrated transcriptomics revealed that MAITregs preferred glycolysis, which was supported by chromatin remodeling at glycolytic gene loci. Functionally, glycolysis in MAITregs favored their IL-10 production but inhibited Th1 cytokines, whereas oxidative phosphorylation (OXPHOS) promoted their Th1/Th17 cytokines. Our study defines MAITregs as a clonally expanded population whose regulatory potency is strictly governed by cellular metabolism.

Indexed as

GlycolysisMucosal-Associated Invariant T CellsReceptors, Antigen, T-CellChromatin Assembly and DisassemblyCytokinesHumansInterleukin-10Oxidative PhosphorylationTh1 CellsCytokinesInterleukin-10Receptors, Antigen, T-Celldiverse TCR repertoiresglycolysishuman MAITregs

Identifiers

PMID42113450

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.