Evidence map›Paper›PMID 42113449›Full record

ArticleScience China. Life sciences2026

A T4SS effector directly disarms competing antibacterial T6SSs by hijacking their conserved spike component.

Dan Xiong, Jinxing Liao, Zhiyuan Zhang, Julien F Giraud, Xiuyuan Li, Dongjing Cheng, Bingxin Wang, Limin Wang, Xiaolong Shao, Long Lin and 5 more

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dan XiongState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Jinxing LiaoHunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Plant Pests, College of Plant Protection, Hunan Agricultural University, Changsha, 430070, China.
Zhiyuan ZhangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Julien F GiraudLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie de la Méditerranée (IMM), Aix-Marseille Université, Centre National de la Recherche Scientifique, Marseille, Cedex 07, 13284, France.
Xiuyuan LiState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Dongjing ChengState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Bingxin WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Limin WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Xiaolong ShaoState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Long LinState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Jinshui ZhengNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Xiangyang LiState Key Laboratory of Green Pesticide, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Fengquan LiuKey Laboratory of Agricultural Microbiology, Department of Plant Pathology, College of Agriculture, Guizhou University, Guiyang, 550025, China.
Eric CascalesLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie de la Méditerranée (IMM), Aix-Marseille Université, Centre National de la Recherche Scientifique, Marseille, Cedex 07, 13284, France.
Guoliang QianState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China. glqian@njau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interspecies competition plays a crucial role in shaping microbial community dynamics and influencing host-associated outcomes. However, the mechanisms by which microbes directly neutralize the antimicrobial systems of their rivals remain largely unexplored. Here, we demonstrate that a bacterial effector protein, translocated via the widely distributed type IV secretion system (T4SS), directly disarms the antibacterial type VI secretion system (T6SS) of a competitor. Specifically, we show that Lysobacter enzymogenes, a ubiquitous soil bacterium, uses its bacterial-killing T4SS (T4SS

Indexed as

Bacterial ProteinsLysobacterPseudomonas putidaType IV Secretion SystemsType VI Secretion SystemsAnti-Bacterial AgentsProtein BindingAnti-Bacterial AgentsBacterial ProteinsType IV Secretion SystemsType VI Secretion SystemsLqqE1LysobacterPseudomonastype IV secretion systemtype VI secretion system

Identifiers

PMID42113449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.