Evidence map›Paper›PMID 42113395›Full record

Observational studySleep & breathing = Schlaf & Atmung2026

Exploratory serum biomarker profiling in idiopathic REM sleep behavior disorder: evidence of early neurodegenerative signatures: a pilot study.

Danielle Mesquita Torres, Fábio Henrique Queiroz Pereira, Marylane da Silva Viana, Mariana Michilles Santos Ramos, Elisa Gabriela Barros Cunha, Leonardo José Rodrigues de Araújo Melo, Emmanuelle Silva Tavares Sobreira, Francisca Charliane Almino Lopes, Annyta Fernandes Frota, Michelle Verde Ramos Soares and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Danielle Mesquita TorresPostgraduate Program in Translational Medicine, Universidade Federal do Ceará, Fortaleza, Brazil. daniellemesquita@hotmail.com.
Fábio Henrique Queiroz PereiraPostgraduate Program in Translational Medicine, Universidade Federal do Ceará, Fortaleza, Brazil.
Marylane da Silva VianaDepartment of Physiology and Pharmacology, Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Mariana Michilles Santos RamosFaculty of Medicine, Division of Neurology, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Elisa Gabriela Barros CunhaFaculty of Medicine, Division of Neurology, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Leonardo José Rodrigues de Araújo MeloFaculty of Medicine, Division of Neurology, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Emmanuelle Silva Tavares SobreiraFaculty of Medicine, Division of Neurology, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Francisca Charliane Almino LopesPostgraduate Program in Translational Medicine, Universidade Federal do Ceará, Fortaleza, Brazil.
Annyta Fernandes FrotaDepartment of Physiology and Pharmacology, Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Michelle Verde Ramos SoaresDepartment of Physiology and Pharmacology, Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Ricardo Titze- de-AlmeidaUniversidade de Brasília, Brasília, DF, Brazil.
Pedro Braga-NetoFaculty of Medicine, Division of Neurology, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Danielle S MacedoDepartment of Physiology and Pharmacology, Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Manoel Alves Sobreira-NetoFaculty of Medicine, Division of Neurology, Universidade Federal do Ceará, Fortaleza, CE, Brazil. manoelsobreira@yahoo.com.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdiopathic REM sleep behavior disorder (iRBD) indicates an early α-synucleinopathy, offering a window for early detection and intervention.

objectiveExplore a serum-based biomarker panel, comprising NfL, GFAP, t-tau, and UCH-L1, in patients with iRBD, and compare to individuals with synucleinopathy and healthy controls.

methodThis is a cross-sectional, observational study. Serum biomarkers were measured using the single molecule array technique. Clinical evaluation included standardized assessments of sleep, cognitive function, motor symptoms, and psychiatric features.

resultsGFAP levels were significantly higher in the iRBD group than in the control and synucleinopathy groups. Serum NfL levels yielded conflicting results. T-tau and UCHL-1 protein levels were lower in the iRBD and synucleinopathy groups compared to the control group.

conclusionOur findings suggest that serum levels of NfL, GFAP, t-tau, and UCH-L1 may serve as potential biomarkers in iRBD, primarily GFAP levels.

Indexed as

BiomarkersGlial Fibrillary Acidic ProteinNeurofilament ProteinsREM Sleep Behavior DisorderSynucleinopathiestau ProteinsUbiquitin ThiolesteraseAgedCross-Sectional StudiesEarly DiagnosisFemaleHumansMaleMiddle AgedPilot ProjectsBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau ProteinsUbiquitin ThiolesteraseUCHL1 protein, humanBiomarkerNeurodegenerationREM sleep behavior disorderSynucleinopathies

Identifiers

PMID42113395
PMCPMC13161332

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.