ArticleJA clinical reports2026
Intraoperative hemodynamic collapse revealing undiagnosed pheochromocytoma in a patient with neurofibromatosis type 1 and severe cervical deformity: a case report on perioperative management.
Article in JA clinical reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPatients with neurofibromatosis type 1 (NF1) have a 0.1-5.7% incidence of pheochromocytomas. Blood pressure control is difficult in cases of undiagnosed pheochromocytomas without preoperative treatment. CASE PRESENTATION: A 39-year-old woman with NF1 and severe cervical deformity presented with progressive quadriplegia and underwent urgent halo-vest placement. A large adrenal mass was incidentally detected on preoperative computed tomography (CT) scans; however, no further examination was performed because the patient had no symptoms suggestive of pheochromocytoma and her cervical spinal condition was considered urgent. When hemodynamic instability occurred during surgery, pheochromocytoma was suspected, and the diagnosis was confirmed postoperatively. Fourteen months later, the tumor was safely resected using strict preoperative management with metyrosine and alpha-blockers and a careful surgical plan.
conclusionsThis case highlights the importance of thorough preoperative screening and the role of anesthesiologists in detecting pheochromocytomas in asymptomatic patients with NF1 who present with intraoperative hemodynamic instability.
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