ReviewDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2026
Pharmaceutically engineered olfactory-masking agents: Innovating oral drug delivery through multisensory excipient design.
Review in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Taste Modulation by Umami Compounds: Mechanisms, Sensor-Based Evaluation, and Pharmaceutical Applications in Bitterness Suppression.Sensors (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enhancing patient adherence to oral medication administration is still exceedingly difficult, especially for sensitive, elderly, and pediatric groups. Techniques for disguising taste are widely known, but olfactory modulation, which is a crucial factor in determining palatability and adherence, has received little attention. This review integrates concepts from formulation science, medicinal chemistry, and sensory neuroscience to examine the new subject of scent-masking through creative excipient techniques. We explore the physiological processes implicated in scent-triggered aversion and offer mechanistic insights into the effect of olfactory perception on medication tolerance. In order to reduce offensive odours, the review focuses on important excipient technologies that encapsulate, absorb, or change volatile substances, such as cyclodextrins, aroma-blocking polymers, lipid-based carriers, and natural odour-neutralizers. The dual function of nanostructured lipid carriers (NLCs) and advanced microencapsulation in odour control and controlled medication release is reviewed. We also evaluate how pharmacokinetics, bioavailability, and formulation stability are affected by excipient-API interactions. Analytical methods for assessing scent-masking efficacy are examined, including spectroscopy, thermogravimetric measurement, and electronic tongue (e-tongue). Scent-masked formulations have been shown to enhance adherence and increase therapeutic results in clinical case studies. We also go over regulatory issues and the necessity of updating frameworks to deal with olfactory excipients. Potential future developments in pharmaceutical design are examined, including bioresponsive fragrance-release devices, AI-driven scent modeling, and 3D-printed dosage forms. This research highlights a paradigm shift toward patient-centric oral formulations that maximize therapeutic efficacy through sensory engineering by promoting multisensory-driven excipient innovation, particularly in fragrance modulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.