Evidence map›Paper›PMID 42113341›Full record

ArticleEpilepsia2026

Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats.

Auriane Apaire, Elise Collard, Abigail Niyibizi, Natasha N Kumar, Enrique Germany Morrison, Javier Chavez Cerda, Ayse S Dereli, Riem El Tahry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Auriane ApaireClinical Neuroscience, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID https://orcid.org/0009-0003-2062-104X
Elise CollardClinical Neuroscience, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID https://orcid.org/0009-0008-1576-9142
Abigail NiyibiziClinical Neuroscience, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID https://orcid.org/0009-0006-2864-9591
Natasha N KumarDepartment of Pharmacology, School of Biomedical Sciences, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0003-4712-8792
Enrique Germany MorrisonClinical Neuroscience, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID https://orcid.org/0000-0002-3100-187X
Javier Chavez CerdaSystems & Cognitive Neuroscience, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID https://orcid.org/0000-0003-1155-6701
Ayse S DereliClinical Neuroscience, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID https://orcid.org/0000-0002-5584-197X
Riem El TahryClinical Neuroscience, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID https://orcid.org/0000-0002-2440-0194

Funding

Walloon excellence in life sciences and biotechnology X.2001.22
6 · The paper itself

Abstract

objectiveCardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic-clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic kainic acid (KA) rats, a temporal lobe epilepsy model with focal to bilateral tonic-clonic seizures. However, how this impairment emerges during epileptogenesis and whether it is influenced by day/night period remain unclear. Here, we aimed to investigate the progress of hypercapnic cardioventilatory responses through the epileptogenesis of KA rats and whether it is affected by day or night.

methodsVentilatory or breathing frequency (f

resultsIn healthy rats, cardioventilatory responses to hypercapnia remained stable over time, with increased f SIGNIFICANCE: These findings indicate that cardioventilatory responses are decreased during epileptogenesis in the KA model, suggesting their potential utility for evaluating SUDEP risk.

Indexed as

EpilepsyEpilepsy, Temporal LobeHeart RateHypercapniaAnimalsDisease Models, AnimalKainic AcidMaleRatsRats, Sprague-DawleyRespiratory RateSudden Unexpected Death in EpilepsyKainic Acidcentral respiratory chemoreceptionepilepsyepileptogenesishypercapnic ventilatory responsekainic acid

Identifiers

PMID42113341
PMCPMC13525589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.