Evidence map›Paper›PMID 42113301›Full record

ArticleJournal of fluorescence2026

Aptamer Regulated NIR Carbon Dot/AuNP Fluorescence Sensing Platform for Selective Sarcosine Detection.

Haiyin Huang, Shuping Zhou, Mei Yang, Shenghui Xie, Xiaohua Jiang, Jiahui Yue, Haipeng Yang

Abstract read
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In one paragraph

Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haiyin Huang *Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P.R. China.
Shuping Zhou *Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P.R. China.
Mei YangGuangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P.R. China.
Shenghui XieGuangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P.R. China.
Xiaohua JiangSchool of Undergraduate Education, Shenzhen Polytechnic University, Shenzhen, 518055, P.R. China. jiangxiaohua@szpu.edu.cn.
Jiahui YueGuangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P.R. China.
Haipeng YangGuangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P.R. China. yanghp@szu.edu.cn.

Funding

the National Natural Science Foundation of China 22177077
6 · The paper itself

Abstract

A near-infrared (NIR) fluorescence sensing platform based on NIR carbon dots (CDs), gold nanoparticles (AuNPs) and sarcosine-specific aptamers (SA-Apt) was developed for the sensitive and selective detection of sarcosine (SA), a potential biomarker associated with prostate cancer. Nitrogen- and sulfur-co-doped NIR-CDs were synthesized via a solvothermal method using L-glutathione and formamide, while AuNPs were prepared through a classical citrate-reduction approach. The sensing mechanism is based on an aptamer-regulated inner filter effect (IFE) between NIR-CDs and aggregated AuNPs. In the absence of SA, SA-Apt adsorbs onto the AuNP surface, stabilizing the nanoparticles against salt-induced aggregation and preserving the fluorescence of the NIR-CDs. Upon target recognition, SA-Apt preferentially binds to sarcosine and detaches from the AuNP surface, triggering salt-induced aggregation of AuNPs. This aggregation produces significant spectral overlap with the NIR-CD emission band, resulting in efficient fluorescence quenching via the inner filter effect. The incorporation of NIR-CDs enhances detection sensitivity by providing strong fluorescence emission, minimal background interference, and improved photostability. Under optimized conditions, the NIR-CDs/AuNPs/SA-Apt platform exhibited a linear response to sarcosine over the range of 1-15 µM, with a correlation coefficient (R

Indexed as

Aptamers, NucleotideCarbonCarbon Quantum DotsGoldMetal NanoparticlesSarcosineFluorescenceFluorescent Chemosensor CompoundsHumansInfrared RaysSpectrometry, FluorescenceAptamers, NucleotideCarbonFluorescent Chemosensor CompoundsGoldSarcosineAptamerFluorescence probeGold nanoparticlesNear-infrared carbon dotsSarcosine

Identifiers

PMID42113301

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.