ArticleCurrent microbiology2026
Multi-strain Bacillus Probiotics has Advantages in Improving Abnormal Behavior and Intestinal Flora in Rats of Autism Spectrum Disorder.
Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Autism spectrum disorder (ASD) is a common childhood neurodevelopmental disorder. While many medicines offer therapeutic benefits, they are often associated with adverse side effects. Probiotics, however, present a safer interventional strategy. In this study, we investigated the effects of three probiotic agents: a multi-strain Bacillus formulation, a multi-strain Lactobacillus formulation, and the yeast Saccharomyces boulardii, in a rat model of ASD. The study included a total of 6 groups: a control group with no treatment, an ASD model group induced by valproate (VPA), and three probiotic intervention groups. The results showed that multi-strain Bacillus probiotics treatment was the most significant in alleviating VPA-induced autism in rats. Multi-strain Bacillus probiotics supplementation exerted a significant effect on stereotypic behaviors in ASD rats. Further studies found that multi-strain Bacillus probiotics alleviated ASD symptoms by reducing gut inflammation, optimizing gut microbiota composition and regulating short-chain fatty acid levels. Overall, the study evidence suggested that multi-strain Bacillus probiotics was the most effective for the treatment of VPA-induced ASD rat model.
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