Evidence map›Paper›PMID 42113227›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Radioiodinated compound FJR01: a novel P2X7R-targeted SPECT tracer for visualizing glioma-associated microglia/macrophages in a rat glioblastoma model.

Xiyan Rui, Shengxuan Sun, Yuzhou Ding, Yanshan Li, Xinran Zhao, Fangfei Hu, Zijian Zhou, Nailian Zhang, Chuyi Zhang, Chao Cheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiyan RuiSchool of Pharmaceutical Sciences and Minhang Hospital, Fudan University, Shanghai, China.
Shengxuan SunSchool of Pharmaceutical Sciences and Minhang Hospital, Fudan University, Shanghai, China.
Yuzhou DingSchool of Pharmaceutical Sciences and Minhang Hospital, Fudan University, Shanghai, China.
Yanshan LiSchool of Pharmaceutical Sciences and Minhang Hospital, Fudan University, Shanghai, China.
Xinran ZhaoSchool of Pharmaceutical Sciences and Minhang Hospital, Fudan University, Shanghai, China.
Fangfei HuHuman Phenome Institute, Fudan University, Shanghai, China.
Zijian ZhouSchool of Pharmaceutical Sciences and Minhang Hospital, Fudan University, Shanghai, China.
Nailian ZhangSchool of Pharmaceutical Sciences and Minhang Hospital, Fudan University, Shanghai, China.
Chuyi ZhangInstitute of Epidemiology and Health Care, Faculty of Population Health Sciences, University College London, London, United Kingdom.
Chao ChengChanghai Hospital, Naval Medical University, Shanghai, China.
Bin JiSchool of Pharmaceutical Sciences and Minhang Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The P2X7 receptor (P2X7R) is an imaging biomarker of glioblastoma-associated microglia/macrophages (GAMMs), yet no SPECT tracer is currently available for GAMM imaging. Guided by the high-affinity P2X7R scaffold JNJ-64413739 and molecular docking, we designed two radioiodination-ready analogues, FJR01 and FJR02. Compounds were screened

Indexed as

Brain NeoplasmsGlioblastomaGliomaMacrophagesMicrogliaPurinergic P2X Receptor AntagonistsRadiopharmaceuticalsReceptors, Purinergic P2X7Tomography, Emission-Computed, Single-PhotonAnimalsDisease Models, AnimalDose-Response Relationship, DrugHumansIodine RadioisotopesMaleMiceIodine RadioisotopesPurinergic P2X Receptor AntagonistsRadiopharmaceuticalsReceptors, Purinergic P2X7glioblastomaglioblastoma-associated microglia and macrophages (GAMMs)P2X7 receptor (P2X7R)single photon emission computed tomography (SPECT)tumor microenvironment

Identifiers

PMID42113227
PMCPMC13162550

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.