Evidence map›Paper›PMID 42113221›Full record

ReviewHandbook of experimental pharmacology2026

Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.

Jade L Taylor, Eric A Pereira da Silva, Hannah M Voorhees, Maryann K Ferrara, Sophia Salbato, Nuria Daghbouche-Rubio, Miguel Martín-Aragón Baudel, Madeline Nieves-Cintrón

Abstract readReview
PubMed Publisher
In one paragraph

Review in Handbook of experimental pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jade L TaylorDepartment of Pharmacology, University of California, Davis, CA, USA.
Eric A Pereira da SilvaDepartment of Pharmacology, University of California, Davis, CA, USA.
Hannah M VoorheesDepartment of Pharmacology, University of California, Davis, CA, USA.
Maryann K FerraraDepartment of Pharmacology, University of California, Davis, CA, USA.
Sophia SalbatoDepartment of Pharmacology, University of California, Davis, CA, USA.
Nuria Daghbouche-RubioDepartment of Pharmacology, University of California, Davis, CA, USA.
Miguel Martín-Aragón BaudelDepartment of Pharmacology, University of California, Davis, CA, USA.
Madeline Nieves-CintrónDepartment of Pharmacology, University of California, Davis, CA, USA. mcnieves@ucdavis.edu.ORCID https://orcid.org/0000-0003-1935-8400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic syndrome (MetS) encompasses an interconnected set of risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and systemic inflammation, all of which significantly increase the risk of cardiovascular diseases (CVDs). This chapter provides an overview of animal models used to study cardiovascular complications associated with MetS. We examine commonly used models, including monogenic and polygenic rodent strains, diet-induced and chemically induced models, and large-animal systems, and discuss their strengths and limitations. The chapter then explores cardiac and vascular alterations in MetS and translation to humans. By integrating findings from diverse experimental models with human clinical data, the chapter aims to advance understanding of research on MetS-associated cardiovascular complications.

Indexed as

Cardiovascular DiseasesDisease Models, AnimalMetabolic SyndromeAnimalsHumansdb/dbDiabetesGLP-1HFpEFHypertensionMyogenic toneObesitySGLT2

Identifiers

PMID42113221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.