Biosynthesis of gold nanoparticles from Solanum marginatum and its enhanced anti inflammatory activity in LPS induced RAW 264.7 cell lines.

Gebremichael Abrha Gebreyesus, Tesfay Welderfael, K Krishna Chaithanya, Berihu Tekluu, Taame Abraha Berhe

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Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Gebremichael Abrha GebreyesusDepartment of Chemistry, Adigrat University, Adigrat, Ethiopia.

Tesfay WelderfaelDepartment of Chemistry, Aksum University, Aksum, Ethiopia. weltesf@gmail.com.

K Krishna ChaithanyaDepartment of Chemistry, Aksum University, Aksum, Ethiopia.

Berihu TekluuDepartment of Chemistry, Aksum University, Aksum, Ethiopia.

Taame Abraha BerheDepartment of Chemistry, Adigrat University, Adigrat, Ethiopia.

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6 · The paper itself

Abstract

Nowadays, there is an increase in the demand for plant-extract-mediated nanoparticles, mainly due to low toxicity and biocompatibility, which owing to their enhanced bioavailability, exhibit significant antibacterial, anti-inflammatory, antitumoral, and antiviral activities. However, green synthesis of gold nanoparticles (SM-Au NPs) offers a sustainable targeted and effective way for drug delivery. This study first report to our knowledge demonstrated that gold nanoparticles (SM-Au NPs) synthesized from aqueous leaf extract of Solanum marginatum (SM), evaluated their in-vitro anti-inflammatory activity and their underlying mechanism in Lipopolysaccharide (LPS) induced RAW 264.7 cells. The peak at UV-Vis 540 nm confirmed formation of SM-Au NPs. Dynamic light scattering (DLS) of SM-Au NPs revealed a hydrodynamic size of 1253.3 nm and zeta potential of - 21.1 mV. X-ray diffraction (XRD) analysis revealed that SM-Au NPs were crystalline and pure with an average crystal size of 22.3 nm. The cytotoxicity results confirmed that SM-Au NPs were found to be did not show cytotoxic effect within the concentration of 6.25-12.5 µg/mL against RAW 264.7 macrophages. SM-Au NPs inhibited nitric oxide (NO) production in a dose-dependent manner showing 45.31% inhibition at 12.5 µg/mL with IC

Indexed as

Anti-inflammatoryGold nanoparticlesGreen synthesisRAW 264.7 cellsSolanum marginatum

Identifiers

PMID42113069

DOI10.1186/s11671-026-04634-2

PMCPMC13161458

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