ArticlePediatric surgery international2026
Macrophage subtypes distinguish the hepatic lobule from portal area as sites of inflammation and fibrosis in liver of patients with biliary atresia.
Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeBiliary atresia (BA) has potential immune-mediated pathogenesis involving CD4 + Th1 and Th17 cells. We therefore examined antigen-presenting cells to elucidate their etiopathogenetic mechanisms.
methodsThis study cohort included 17 patients with BA and 15 controls (8 normal controls [NCs] and 7 clinical inflammation controls [CICs]). We focused on CD86
resultsIn the BA group, M1 macrophages in all regions and non-M1 macrophages in the IF and PA were significantly increased compared to those in the NC group. Notably, M1 macrophages often clustered in the IF, and non-M1 macrophages in the PA showed a small spindle-shaped morphology. Non-M1 macrophages in the IF showed a significant positive correlation with alanine aminotransferase, direct bilirubin, and fibrotic area.
conclusionsM1 macrophages were detected as the major population in the HL and IF in BA, whereas non-M1 macrophages in the PA were correlated with hepatic fibrosis. CD86
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