Evidence map›Paper›PMID 42112885›Full record

ArticleAnnals of medicine2026

The effect of internal jugular vein reflux on ischemic stroke with cerebral microbleeds: a prospective clinical study.

Yibo He, Jian Deng, Yetao Lin, Chenyong Zhao, Siyan Chen, Yitao He

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Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yibo HeDepartment of Neurology, Shenzhen People's Hospital, (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern, University of Science and Technology), Shenzhen, China.ORCID 0000-0003-3915-5707
Jian DengDepartment of Neurology, Shenzhen People's Hospital, (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern, University of Science and Technology), Shenzhen, China.ORCID 0000-0003-1956-081X
Yetao LinDepartment of Neurology, Shenzhen People's Hospital, (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern, University of Science and Technology), Shenzhen, China.ORCID 0009-0003-5077-5680
Chenyong ZhaoDepartment of Neurology, Shenzhen People's Hospital, (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern, University of Science and Technology), Shenzhen, China.ORCID 0000-0001-9190-538X
Siyan ChenDepartment of Neurology, Shenzhen People's Hospital, (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern, University of Science and Technology), Shenzhen, China.ORCID 0000-0002-3898-8603
Yitao HeDepartment of Neurology, Shenzhen People's Hospital, (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern, University of Science and Technology), Shenzhen, China.ORCID 0000-0003-3399-3144

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIschemic stroke combined with cerebral microbleeds (CMBs) might lead to the exacerbation of neurological deficits, and this prospective study was to evaluate whether internal jugular vein reflux (IJVR) could be an independent risk factor for ischemic stroke with CMBs.

methods71 patients meeting the criteria were enrolled and underwent head magnetic resonance imaging susceptibility-weighted imaging, ultrasound of the jugular vein, and other relevant examinations. Univariate, multivariate, and subgroup analyses were conducted to assess the relationship between IJVR and ischemic stroke with CMBs.

resultsThere were 31 ischemic stroke patients with CMBs and 40 ischemic stroke patients without CMBs were included. Age, proportion of hypertension, IJVR, activated partial thromboplastin time, and blood uric acid level were all significantly higher in ischemic stroke patients with CMBs than in those without CMBs (

conclusionIJVR might be an independent risk factor for ischemic stroke with CMBs.

Indexed as

Brain IschemiaCerebral HemorrhageIschemic StrokeJugular VeinsStrokeAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRisk Factorscerebral microbleedshypertensionInternal jugular vein refluxIschemic strokerisk factors

Identifiers

PMID42112885
PMCPMC13162556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.