Evidence map›Paper›PMID 42112802›Full record

ArticleMicrobiology spectrum2026

Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies.

Caio César Barbosa Bomfim, Natacha Faivre, Thomas Benoist, Manon Popis, Bastien Suire, David Pericat, José Manuel Sánchez-López, Beatriz Melissa Aponte-Castillo, Emmanuelle Näser, Pénélope Viana and 12 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Caio César Barbosa Bomfim *Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-1998-9237
Natacha Faivre *Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0009-0008-0330-5519
Thomas BenoistInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-0116-2629
Manon PopisInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.
Bastien SuireInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.
David PericatInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.
José Manuel Sánchez-LópezInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0002-1349-4746
Beatriz Melissa Aponte-CastilloUnidad de Investigación Médica en Genética Humana (UIMGH), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, México.ORCID 0009-0004-5613-4718
Emmanuelle NäserInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.
Pénélope VianaInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-0098-4831
Nicolas GuibertService de Pneumologie, Hôpital Larrey, CHU de Toulouse, Toulouse, France.
Romain VergéInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.
Julien MazièresService de Pneumologie, Hôpital Larrey, CHU de Toulouse, Toulouse, France.
Arnaud MétaisInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0002-9538-0338
Renaud PoinclouxInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-2884-1744
Brigitte Raynaud-MessinaInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0009-0000-1512-0871
Fabrice DumasInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0002-9164-4527
Olivier NeyrollesInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-0047-5885
Christel VérolletInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0002-1079-9085
Etienne MeunierInstitut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0002-3651-4877
Geanncarlo Lugo-Villarino *Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-4620-8491
Céline Cougoule *Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0002-6795-5448

Funding

Agence Nationale de Recherches sur le Sida et les Hépatites Virales 2022-ECTZ190463, 2022-ECTZ205302, 2023-ECTZ293306Bill and Melinda Gates Foundation INV-046428Fondation pour la Recherche Médicale EQU202303016313H2020 Health 101080462Sidaction 22-2-AEQ-13457-1UK Research and Innovation 101080462
6 · The paper itself

Abstract

Tuberculosis (TB) remains a major global health challenge that requires new therapeutic strategies to improve drug efficacy, shorten treatment duration, prevent drug resistance, and limit IMPORTANCE: Tuberculosis remains one of the world's deadliest infectious diseases. The development of new therapies is limited by the absence of human-relevant models that reproduce the distinct lung niches encountered by

Indexed as

Antitubercular AgentsHost-Directed TherapyLungMacrophages, AlveolarMycobacterium tuberculosisTuberculosisCells, CulturedHumansTuberculosis, PulmonaryAntitubercular Agentsair–liquid interface culturesalveolar macrophagesantibioticsantimicrobial efficacyhost-directed therapyMycobacterium tuberculosis

Identifiers

PMID42112802
PMCPMC13227965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.