Evidence map›Paper›PMID 42112765›Full record

ArticleThe International journal of eating disorders2026

When Is Improvement Possible? A Necessity-Based Analysis of Short-Term Eating Disorder Symptom Improvement During Inpatient Treatment.

Paolo Meneguzzo, Patrizia Todisco

Abstract read
In one paragraph

Article in The International journal of eating disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paolo MeneguzzoDepartment of Neuroscience, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0003-3323-6071
Patrizia TodiscoEating Disorder Unit, Casa di Cura "Villa Margherita" - KOS Group, Arcugnano, Italy.ORCID https://orcid.org/0000-0002-2212-9855

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEating-disorder-specific functional impairment may represent a boundary condition for treatment response, yet this possibility has rarely been examined. We investigated whether baseline functional impairment constrains short-term eating-disorder symptom improvement, indexed by change in EDE-Q Global scores during inpatient treatment using a necessity-based framework.

methodWe retrospectively analyzed 462 inpatients who completed the Eating Disorder Examination Questionnaire (EDE-Q 6.0) at admission and discharge. Functional impairment (Clinical Impairment Assessment, CIA), general psychopathology (SCL-90-R GSI), and body uneasiness (BUT-GSI) were assessed at baseline. Short-term eating-disorder symptom improvement was defined as clinically meaningful improvement based on the Reliable Change Index and as continuous change in EDE-Q Global scores. Necessary condition analysis with permutation testing and bottleneck analysis was applied, with subgroup analyses for anorexia nervosa versus non-anorexia nervosa.

resultsED-specific functional impairment emerged as a statistically significant necessary condition for clinically meaningful improvement (NCA d = 0.167, p = 0.011) and symptom change (d = 0.159, p = 0.002). Neither general psychopathology nor body uneasiness met criteria for necessity. Bottleneck analysis showed that larger symptom reductions occurred only above increasing CIA thresholds. Necessity effects were robust in AN but absent in non- diagnoses. DISCUSSION: Functional impairment appears to constrain short-term inpatient EDE-Q improvement in anorexia nervosa, whereas no necessity effect was observed in non-anorexia nervosa diagnoses. These findings suggest that ED-specific functional impairment may function as a boundary condition for short-term EDE-Q improvement in anorexia nervosa within the present sample, whereas no corresponding necessity effect was observed for general psychopathology, body uneasiness, or non-anorexia nervosa diagnoses.

Indexed as

Feeding and Eating DisordersAdolescentAdultAnorexia NervosaFemaleHospitalizationHumansInpatientsMaleRetrospective StudiesSurveys and QuestionnairesTreatment OutcomeYoung Adulteating disordersEDE‐Q improvementfunctional impairmentinpatient treatmentnecessary condition analysistreatment outcome

Identifiers

PMID42112765
PMCPMC13536211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.