Evidence map›Paper›PMID 42112667›Full record

ArticleThe journal of physical chemistry. B2026

Reframing Triazoloacridinone C-1305 as a G-Quadruplex Pharmacophore.

Julia Pakuła, Julia Borzyszkowska-Bukowska, Monika Pawłowska, Rafał Tomaszczyk, Karolina Zielińska, Ewa Paluszkiewicz, Tomasz Laskowski

Abstract read
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In one paragraph

Article in The journal of physical chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia PakułaDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, Gdańsk 80-233, Poland.
Julia Borzyszkowska-BukowskaDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, Gdańsk 80-233, Poland.
Monika PawłowskaDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, Gdańsk 80-233, Poland.
Rafał TomaszczykDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, Gdańsk 80-233, Poland.
Karolina ZielińskaInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Zygmunta Noskowskiego Str. 12/14, Poznań 61-704, Poland.
Ewa PaluszkiewiczDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, Gdańsk 80-233, Poland.
Tomasz LaskowskiDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, Gdańsk 80-233, Poland.ORCID 0000-0003-4868-2381

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

What was once assigned as GGG intercalation can, in retrospect, be read as G-quadruplex recognition. Here, we reframe the clinically investigated triazoloacridinone C-1305 as a high-affinity ligand of the c-MYC promoter G4 model Pu22. UV-Vis speciation resolved four spectral forms and yielded three macroscopic p

Indexed as

AcridinesAcridonesG-QuadruplexesTriazolesHumansLigandsPharmacophorePromoter Regions, GeneticAcridinesAcridonesC 1305LigandsTriazoles

Identifiers

PMID42112667
PMCPMC13309005

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.