Evidence map›Paper›PMID 42112651›Full record

ArticleInnate immunity

Tn-Glycoconjugates engage MGL2 to potentiate TLR9-mediated dendritic cell maturation and Th1-skewed immune responses.

Carolina Chiale, Sylvie Bay, Christelle Ganneau, Teresa Freire

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carolina ChialeLaboratorio de Inmunomodulación y Vacunas, Unidad Académica de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Sylvie BayUnité de Chimie des Biomolécules, Institut Pasteur, Université Paris Cité, CNRS UMR3523, Paris, France.
Christelle GanneauUnité de Chimie des Biomolécules, Institut Pasteur, Université Paris Cité, CNRS UMR3523, Paris, France.
Teresa FreireLaboratorio de Inmunomodulación y Vacunas, Unidad Académica de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.ORCID 0000-0002-7808-8845

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) orchestrate antitumor immunity by integrating signals from the tumor microenvironment to prime effective T cell responses. Many tumors display altered glycosylation patterns, including tumor-associated carbohydrate antigens (TACAs) such as the Tn antigen (GalNAcα1-

Indexed as

Antigens, Tumor-Associated, CarbohydrateAsialoglycoproteinsDendritic CellsGlycoconjugatesLectins, C-TypeTh1 CellsToll-Like Receptor 9AnimalsCell DifferentiationCells, CulturedHumansLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutSignal TransductionAntigens, Tumor-Associated, CarbohydrateAsialoglycoproteinsGlycoconjugatesLectins, C-TypeMGL2 protein, mouseTlr9 protein, mouseTn antigenToll-Like Receptor 9Toll-Like Receptor AgonistsDendritic cellsMGL2Th1 immune responseTLR9Tn antigen

Identifiers

PMID42112651
PMCPMC13172724

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.