ArticleEuropean journal of neurology2026
HLA Class I Haplotype in Glutamic Acid Decarboxylase Antibody-Associated Neurological Disease.
Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectGlutamic acid decarboxylase antibody-associated neurological disease (GADAND) is a rare autoimmune disorder with elusive immunogenetic underpinnings. We aimed to investigate HLA associations with GADAND susceptibility in a Chinese cohort.
methodsWe performed HLA genotyping at the HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 loci in 62 Chinese patients with GADAND and compared them with 990 healthy controls. Haplotype frequencies were estimated using the expectation-maximization (EM) algorithm. Allele and haplotype associations with disease susceptibility and clinical phenotypes were assessed.
resultsWe identified the HLA class I haplotype A*11:01 ~ B*40:01 ~ C*07:02 as a susceptibility haplotype for GADAND (OR = 10.22, 95% CI 3.86-25.57, p
conclusionsThe haplotype A*11:01 ~ B*40:01 ~ C*07:02 was associated with GADAND susceptibility in the Chinese population, implicating T cell involvement. T1DM-associated haplotypes were overrepresented in GADAND, and A*11:01 ~ B*40:01 ~ C*07:02 was enriched in comorbid AITD, suggesting HLA as a shared immunogenetic basis for autoimmune comorbidities. No significant HLA associations with clinical phenotypes were identified, warranting validation in larger cohorts.
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