ReviewCell cycle (Georgetown, Tex.)2026
Microenvironment stiffness regulates cell cycle.
Review in Cell cycle (Georgetown, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
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Abstract
The cell cycle is a highly conserved and ordered process that regulates cell proliferation under physiological and pathological conditions. Among the physical properties of the cellular microenvironment, the extracellular matrix (ECM) stiffness is a crucial regulator of cellular behavior. Emerging research suggests a strong relationship between ECM stiffness and cell cycle progression, although the underlying mechanisms remain unclear. In various diseases, including cancer, neurological disorders, and fibrosis, both ECM stiffness and the cell cycle are tightly involved, thereby influencing disease progression. In addition, ECM stiffness varies across tissues as the disease progresses. This review summarizes current findings on the mechanotransduction pathway through which microenvironmental stiffness regulates the cell cycle across different cell types and stiffness ranges. We also discuss the limitations of the current research and future directions for deepening our understanding of how physical cues in the microenvironment modulate cell cycle control.
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