Evidence map›Paper›PMID 42112590›Full record

ArticleMediators of inflammation2026

Identification of Immune-Related Lactylation Genes in Rheumatoid Arthritis With Atherosclerosis: A Comprehensive Analysis Using Bulk and Single-Cell RNA Sequencing Data.

Jiaqi Hu, Weiyu Tao, Xinyu Qian, Qilong Liu, Zhengyi Jin, Ruina Kong, Jie Gao

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PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiaqi HuDepartment of Rheumatology and Immunology, Zhongshan Hospital Fudan University, Shanghai, 200032, China, fudan.edu.cn.
Weiyu TaoDepartment of Rheumatology and Immunology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China, smmu.edu.cn.
Xinyu QianDepartment of Rheumatology and Immunology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China, smmu.edu.cn.
Qilong LiuDepartment of Rheumatology and Immunology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China, smmu.edu.cn.
Zhengyi JinDepartment of Rheumatology and Immunology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China, smmu.edu.cn.
Ruina KongDepartment of Rheumatology and Immunology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China, smmu.edu.cn.ORCID https://orcid.org/0009-0005-3545-0655
Jie GaoDepartment of Rheumatology and Immunology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China, smmu.edu.cn.ORCID https://orcid.org/0000-0003-1075-3631

Funding

Basic Medical Research Special Surface Cultivation Project of the First Affiliated Hospital of Naval Medical University 2023PY40National Natural Science Foundation of China 82571999Natural Science Foundation of the Shanghai Higher Education Institutions of China 21ZR1478900Scientific research Project of Shanghai Municipal Health Commission 202340061Training Program for Young Rheumatologists in Pujiang SPROG2406
6 · The paper itself

Abstract

backgroundGrowing evidence demonstrates that rheumatoid arthritis (RA), a chronic autoimmune disease characterized by joint inflammation and immune system dysfunction, can significantly accelerate the progression of atherosclerosis (AS). Studies have revealed that patients with RA and AS share numerous common features in terms of immune dysregulation and metabolic alterations, with abnormalities in lactate metabolism being particularly prominent. However, the role of lactate and its associated protein modification-lactylation-in the pathogenesis of RA-related AS remains unclear. The primary objective of this study is to comprehensively investigate lactylation-related genes as potential diagnostic markers for patients with concurrent RA and AS.

methodsWe identified the core genes associated with lactylation by integrating and analyzing two disease-related datasets: a RA dataset (GSE89408) and an AS dataset (GSE43292) from the GEO database. Through comprehensive analysis, we examined the functions associated with the hub genes and investigated the correlation between their expression levels and immune infiltration. Additionally, we explored the lactylation scores of different immune cells using single-cell data.

resultsWe identified four lactylation-related hub genes (SMARCC2, CCNA2, NUP50, and GATAD2B) highly associated with concurrent RA and AS, which showed high diagnostic potential (area under the curve [AUC] > 0.88). Further analysis revealed that these four hub genes were significantly correlated with the level of immune cell infiltration. To better understand the relationship between lactylation and immune cells, we analyzed single-cell sequencing data, which demonstrated significant differences in lactylation scores across various types of immune cells.

conclusionsThese findings highlight lactylation-related genes as promising diagnostic markers and provide insights into shared pathogenic mechanisms of RA and AS.

Indexed as

Arthritis, RheumatoidAtherosclerosisHumansSequence Analysis, RNASingle-Cell AnalysisSingle-Cell Gene Expression Analysisatherosclerosisimmune infiltrationlactylationrheumatoid arthritis

Identifiers

PMID42112590
PMCPMC13159083

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