Evidence map›Paper›PMID 42112559›Full record

SynthesisPsychological medicine2026

Risk factors associated with blood dyscrasia during clozapine treatment: a systematic review and meta-analysis.

Cecilia Casetta, Emilia Loane, David Taylor, Richard Emsley, James Hunter MacCabe

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cecilia CasettaInstitute of Psychiatry at the Maudsley: King's College London Institute of Psyc, UK.ORCID 0000-0002-1980-3415
Emilia LoaneInstitute of Psychiatry at the Maudsley: King's College London Institute of Psyc, UK.
David Taylorhttps://ror.org/015803449SLAM: South London and Maudsley NHS Foundation Trust, UK.
Richard EmsleyInstitute of Psychiatry at the Maudsley: King's College London Institute of Psyc, UK.ORCID 0000-0002-1218-675X
James Hunter MacCabeInstitute of Psychiatry at the Maudsley: King's College London Institute of Psyc, UK.ORCID 0000-0002-6754-1018

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clozapine is the only effective treatment for treatment-resistant schizophrenia, but concerns over blood dyscrasia and need for monitoring limit its use. Evidence suggests many hematological abnormalities may result from surveillance bias, with agranulocytosis being the primary adverse effect directly induced by clozapine. This systematic review (PROSPERO: CRD42024487199) investigates non-genetic risk factors associated with blood dyscrasia during clozapine treatment, focusing on neutropenia and agranulocytosis. Random-effect meta-analyses were performed on studies reporting quantitative risk data. Due to inconsistent neutropenia definitions, analyses used absolute neutrophil count (ANC) thresholds of <2000/mm

Indexed as

AgranulocytosisAntipsychotic AgentsClozapineNeutropeniaSchizophrenia, Treatment-ResistantFemaleHumansRisk FactorsSchizophreniaAntipsychotic AgentsClozapineagranulocytosisblood dyscrasiaclozapineneutropeniaschizophreniatreatment resistant psychosis

Identifiers

PMID42112559
PMCPMC13161814

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.