Evidence map›Paper›PMID 42112340›Full record

SynthesisFrontiers in immunology2026

Identification of new overlapping and disease-specific genetic risk factors for rheumatoid arthritis and radiographic axial spondyloarthritis: a meta-analysis of three large European populations and functional characterization.

Antonio José Cabrera-Serrano, María Carretero-Fernández, Begoña Pérez-Rojo, Rob Ter Horst, Marisa Cañadas-Garre, Helena Canhão, Luca Quartuccio, Signe B Sorensen, Bente Glintborg, Ileana Filipescu and 21 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Antonio José Cabrera-SerranoGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
María Carretero-FernándezGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Begoña Pérez-RojoGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Rob Ter HorstDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands.
Marisa Cañadas-GarreGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Helena CanhãoEpiDoC Unit, CEDOC, NOVA Medical School and National School of Public Health, Universidade Nova de Lisboa, Lisbon, Portugal.
Luca QuartuccioDepartment of Medical Area, Clinic of Rheumatology, University of Udine, Udine, Italy.
Signe B SorensenMolecular Diagnostic and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Jutland, Aabenraa, Denmark.
Bente GlintborgThe DANBIO Registry, The Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
Ileana FilipescuRheumatology Department, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Cluj-Napoca, Romania.
Eva Pérez-PampinRheumatology Unit, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
Pablo Conesa-ZamoraClinical Analysis Department, Santa Lucía University Hospital, Cartagena, Spain.
Jerzy SwierkotDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Wroclaw, Poland.
Alfons A den BroederDepartment of Rheumatology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, Netherlands.
Salvatore de VitaDepartment of Medical Area, Clinic of Rheumatology, University of Udine, Udine, Italy.
Eva Rabing Brix PetersenDepartment of Biochemistry and Immunology. University Hospital of Southern Jutland, Aabenraa, Denmark.
Yang LiDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands.
Marieke J H CoenenDepartment of Human Genetics, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, Netherlands.
Katarzyna Bogunia-KubikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Vibeke AndersenMolecular Diagnostic and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Jutland, Aabenraa, Denmark.
João Eurico FonsecaRheumatology and Metabolic Bone Diseases Department, Hospital de Santa Maria, CHLN, Lisbon, Portugal.
Merete Lund HetlandThe DANBIO Registry, The Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
Miguel Ángel López NevotInstituto de Investigación Biosanitaria IBs.Granada, Granada, Spain.
Clementina López-MedinaRheumatology Department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain.
Fernando Jesús Reyes-ZuritaDepartment of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands.
Alejandro EscuderoRheumatology Department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain.
Rafael CálizRheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain.
Eduardo Collantes-EstévezRheumatology Department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain.
José Manuel Sánchez-MaldonadoGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Juan SainzGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study conducted a meta-analysis across three large European cohorts (UKBB, FinnGen, and REPAIR), including 12,660 rheumatoid arthritis (RA) cases, 2,446 radiographic axial spondyloarthritis (r-axSpA) cases, and over 530,000 shared controls. Methods: Ten independent SNPs in Results: Ten independent SNPs were significantly associated with both RA and r-axSpA. Risk alleles included Discussion: Our findings highlight novel shared and disease-specific variants and key immunoregulatory mediators-IL10, IL22, IL6, CCL25, and HO-1-offering insights for disease stratification and therapeutic targeting.

Indexed as

Arthritis, RheumatoidAxial SpondyloarthritisGenetic Predisposition to DiseaseEuropeHumansPolymorphism, Single NucleotideQuantitative Trait LociRisk Factorsankylosing spondylitisfunctional characterizationgenetic variantsoverlapping and disease-specific genetic markersrheumatoid arthritis

Identifiers

PMID42112340
PMCPMC13149237

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.