Trial reportFrontiers in immunology2026
The protective effect of probiotics on intestinal mucosal injury and dysbiosis in infants with congenital heart disease undergoing cardiopulmonary bypass.
Trial report in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to investigate alterations in intestinal mucosal barrier function and gut microbiota in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass, and to evaluate whether perioperative probiotic administration improves intestinal homeostasis and clinical outcomes. Methods: A randomized, double-blind, placebo-controlled trial was conducted in infants with non-cyanosis CHD in need of surgical correction with CPB. Infants aged 1 month to 1 year were enrolled between June 2021 and July 2022. Participants in the treatment group received perioperative probiotics containing Results: Intestinal mucosal barrier function was impaired after CPB surgery, as evidenced by significant increases in IFABP, DAO, D-LA and CRP levels. Additionally, CPB disrupted microbial diversity, increased the abundance of opportunistic pathogenic bacteria such as Conclusions: Infants with CHD undergoing CPB are at risk for intestinal mucosal barrier impairment and gut microbiota perturbation. Probiotics administration may alleviate intestinal injury and, to some extent, prevent dysbiosis after CPB. Further studies with larger sample sizes are warranted to validate the protective effect of probiotics in this setting.
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