Evidence map›Paper›PMID 42112331›Full record

ArticleFrontiers in immunology2026

Irisin hampers β-amyloid-induced microglial inflammation

Roberta Mancuso, Marina Saresella, Riccardo Nuzzi, Simone Agostini, Ivana Marventano, Ambra Hernis, Francesca La Rosa, Federica Piancone, Mario Clerici

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Roberta MancusoIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Marina SaresellaIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Riccardo NuzziIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Simone AgostiniIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Ivana MarventanoIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Ambra HernisIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Francesca La RosaIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Federica PianconeIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Mario ClericiIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neuroinflammation, which is driven by microglial activation, contributes to neurodegeneration. The myokine irisin exerts anti-inflammatory effects, potentially through microRNA-mediated regulation of inflammasome components. However, the underlying molecular mechanisms remain incompletely defined. In this Methods: For this aim, human immortalized microglia (hTERT) were LPS primed and Aβ Results and discussion: Irisin treatment was associated with reduced Aβ

Indexed as

Amyloid beta-PeptidesFibronectinsInflammationMicrogliaMicroRNAsNLR Family, Pyrin Domain-Containing 3 ProteinToll-Like Receptor 4Cell LineCytokinesHumansInflammasomesSignal TransductionAmyloid beta-PeptidesCytokinesFibronectinsFNDC5 protein, humanInflammasomesMicroRNAsMIRN451 microRNA, humanNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanTLR4 protein, humanToll-Like Receptor 4irisinmicrogliamiR-451aneuroinflammationNLRP3rehabilitation

Identifiers

PMID42112331
PMCPMC13149183

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.