Evidence map›Paper›PMID 42112327›Full record

ArticleFrontiers in immunology2026

PD-1 deficiency exacerbates

Xiaowen Yu, Lu Huang, Jianping Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaowen YuInstitute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing, China.
Lu HuangDepartment of Pathology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Jianping XieInstitute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulmonary Methods: We established a PD-1-deficient mouse model of MAB infection and assessed bacterial clearance, immune responses, and metabolic alterations using colony counting, histopathology, flow cytometry, multiplex immunofluorescence, transcriptomics, and metabolic assays. Results: PD-1 Conclusion: PD-1 deficiency disrupts T cell-neutrophil crosstalk via metabolic reprogramming, resulting in immune dysregulation and exacerbated infection. These findings underscore infection risks linked to PD-1/PD-L1 blockade, informing clinical safety and therapeutic strategies.

Indexed as

Mycobacterium abscessusMycobacterium Infections, NontuberculousNeutrophilsProgrammed Cell Death 1 ReceptorAnimalsCytokinesDisease Models, AnimalLungMetabolic ReprogrammingMiceMice, Inbred C57BLMice, KnockoutCytokinesPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorCD4+ T cellmetabolic reprogrammingMycobacteroides abscessusneutrophilPD-1

Identifiers

PMID42112327
PMCPMC13155127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.