ArticleJournal of inflammation research2026
A Real-World Study of Upadacitinib in Anti-TNF Refractory Crohn's Disease: Effectiveness, Persistence, and Safety.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Real-world evidence on the effectiveness of upadacitinib in Crohn's disease is increasing; however, data from Chinese populations remain limited. This study aimed to evaluate the real-world effectiveness, persistence, and safety of upadacitinib. Methods: This retrospective study included consecutive patients with Crohn's disease treated with upadacitinib at the First Affiliated Hospital of Anhui Medical University who had at least one follow-up visit. Clinical effectiveness was assessed using the Harvey-Bradshaw Index, and endoscopic effectiveness was evaluated using the Simple Endoscopic Score for Crohn's Disease. Logistic regression analysis was performed to identify factors associated with clinical remission at week 12. Kaplan-Meier analysis and Cox regression analysis were used to evaluate upadacitinib persistence. Results: Total of 108 patients with moderate-to-severe Crohn's disease and prior anti-TNF failure or intolerance were included. The clinical remission rates at weeks 12 and 24 were 55.1% and 52.5%, respectively, whereas the biomarker remission rates were 57.3% and 62.5%, respectively. Endoscopic reassessment was available for 32 patients. Endoscopic response was achieved in 16 patients (50.0%), of whom 8 (25.0%) attained endoscopic remission. Pharmacokinetic data from a small subset of 24 patients showed that higher plasma concentrations of upadacitinib were associated with endoscopic remission ( Conclusion: This real-world study demonstrates that upadacitinib is effective, with acceptable safety and favorable treatment persistence, in Chinese patients with moderate-to-severe anti-TNF-refractory Crohn's disease. Future studies with larger sample sizes should focus on long-term effectiveness and safety and provide more comprehensive pharmacokinetic characterization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.