Evidence map›Paper›PMID 42112301›Full record

ArticleIranian journal of microbiology2026

A comparative analysis of CRISPR systems, virulence factors, and antibiotic resistance genes in carbapenem-sensitive and carbapenem-resistant

Samira Saedi, Javad Nezhadi, Hadi Feizi, Mohammad Yousef Memar, Vahid Arefi, Hiva Kadkhoda

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Article in Iranian journal of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Samira SaediDepartment of Medical Microbiology, Khalkhal University of Medical Sciences, Khalkhal, Iran.
Javad NezhadiDepartment of Medical Microbiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Hadi FeiziDeparment of Medical Microbiology, Alinasab Hospital, Sccial Security Organization, Tabriz, Iran.
Mohammad Yousef MemarInfectious and Tropical Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Vahid ArefiDepartment of Medical Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hiva KadkhodaDepartment of Medical Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Materials and Methods: Carbapenemase-producing isolates were identified by mCIM/eCIM. PCR and RT-qPCR detected key genes, including cas3, involved in CRISPR-Cas function. In silico analyses included STRING for protein interactions, CRISPRCasdb for CRISPR subtype distribution, and Phyre2/AlphaFold for cas3 structure prediction. Results: Among the isolates, 35.2% were resistant to carbapenems. Among CRKP strains, high prevalence of Conclusion: This study highlights key differences between CRKP and CSKP isolates, particularly in CRISPR-Cas systems, resistance, and virulence. The findings suggest that cas3 plays a critical role in genomic adaptation and resistance mechanisms in

Indexed as

CRISPR-cas systemsDrug resistanceGene expression regulationKlebsiella pneumoniaeVirulence factors

Identifiers

PMID42112301
PMCPMC13156803

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