Evidence map›Paper›PMID 42112298›Full record

ArticleIranian journal of microbiology2026

Comparative evaluation of outer membrane protein and whole cell antigen vaccine against avian pathogen

Basharat Maqbool Wani, Shayaib Ahmad Kamil, Showkat Ahmad Shah, Masood Saleem Mir, Mir Nadeem Hassan, Zahid Amin Kashoo, Mudasir Ali Rather, Majid Shafi, Zahoor Ahmad Wani, Nadeem Shabir and 3 more

Abstract read
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In one paragraph

Article in Iranian journal of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Basharat Maqbool WaniDepartment of Veterinary Pathology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Shayaib Ahmad KamilDepartment of Veterinary Pathology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Showkat Ahmad ShahDepartment of Veterinary Pathology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Masood Saleem MirDepartment of Veterinary Pathology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Mir Nadeem HassanDepatment of Veterinary Microbiology & Immunology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Zahid Amin KashooDepatment of Veterinary Microbiology & Immunology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Mudasir Ali RatherDepartment of Veterinary Public Health, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Majid ShafiDepartment of Veterinary Pathology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Zahoor Ahmad WaniDepartment of Veterinary Parasitology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Nadeem ShabirDepartment of Animal Biotechnology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Nazli TizroDepartment of the Environment, College of Natural Resources and Environment, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Akeel BashirDepartment of Veterinary Pathology, FVSc & AH, Shuhama, SKUAST-Kashmir, India.
Atif Khurshid WaniDepartment of Veterinary Biochemistry, FVSc & AH, Shuhama, SKUAST-Kashmir, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Present study was aimed at assessing protective efficacy of outer membrane protein (OMP) vaccine in comparison to inactivated whole cell antigen vaccine after challenge with homologous serogroup (O2) of avian pathogenic Materials and Methods: The outer membrane proteins were extracted by sarcosyl method and protein concentration was determined by nanodrop spectrophotometer. The study comprised of 120 birds divided into 6 groups. The birds were subcutaneously immunized twice with primary vaccine in the first week followed by booster vaccine in second week. Results: The protection rate of 82% was found in whole cell inactivated antigen, 91% in OMP vaccine and 27% among the unvaccinated group. The antibody (IgG) response was found significantly higher in OMP vaccine group than whole cell antigen group. In unvaccinated groups chicks, the antibody titer never reached to the protective level till the termination of experiment. The bacteria were re-isolated from the infected broiler chickens for the confirmation of induced infection and were characterized using standard cultural and biochemical tests belonging to O2 serogroup. Conclusion: Our study demonstrated that the outer membrane protein (OMP) vaccine provided significantly higher protection (91%) and antibody response compared to the inactivated whole cell antigen vaccine (82%) against

Indexed as

Bacterial outer membrane proteinsChickensColibacillosisEscherichia coliImmune responseVaccines

Identifiers

PMID42112298
PMCPMC13156834

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.