ArticlemicroPublication biology2026
Let-7 miRNAs are Selectively Sensitive to Dicer Dosage.
Article in microPublication biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
DICER1 syndrome is a rare cancer predisposition disorder linked to disruption of the miRNA biogenesis enzyme Dicer. To model germline DICER1 loss, we generated heterozygous knockout cell lines in mouse and human systems. While global miRNA levels were largely unaffected, the let-7 family was consistently downregulated across all models. The coordinated reduction of both guide and passenger strands, without similar effects on co-transcribed miRNAs, indicates a post-transcriptional biogenesis mechanism. These findings reveal a selective sensitivity of let-7 miRNAs to Dicer dosage and suggest a role for let-7 dysregulation in DICER1-associated tumorigenesis.
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Registered trials
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