ArticleInfection and drug resistance2026
Modulation of
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Methods: Quercetin was extracted from Results: Both treatments significantly reduced lasB- and pqsA-driven GFP reporter activity at sub-inhibitory concentrations (10-100 µM) that did not affect bacterial growth or viability. Inhibition was dose-dependent and more pronounced for the PQS system, accompanied by substantial reductions in extracellular protease activity and strong suppression of biofilm formation and partial dispersal of established biofilms. Molecular docking revealed favourable binding of quercetin to the QS regulators LasR and PqsR, with high-affinity interaction in the PqsR co-inducer pocket, while binding to PqsE was weak and non-specific. Conclusion: These mechanistic insights align with the observed preferential PQS inhibition. The
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.