Evidence map›Paper›PMID 42112213›Full record

ArticleJournal of medicine and life2026

Hospitalization costs of pediatric acute appendicitis in Western Romania: a single-center retrospective study.

Ciprian-Ioan Borca, Madalin-Marius Margan, Corneluta Fira-Mladinescu, Alexandru Cristian Cindrea, Roxana Margan, Cristiana-Smaranda Ivan, Alexandru Alexandru, Ovidiu Alexandru Mederle, Sergiu Bajan, Brigitha Vlaicu and 1 more

Abstract read
In one paragraph

Article in Journal of medicine and life, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ciprian-Ioan BorcaDoctoral School, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Madalin-Marius MarganDiscipline of Public Health, Department of Functional Sciences, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Corneluta Fira-MladinescuDiscipline of Hygiene, Department of Microbiology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Alexandru Cristian CindreaDoctoral School, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Roxana MarganDiscipline of Hygiene, Department of Microbiology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Cristiana-Smaranda IvanDoctoral School, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Alexandru AlexandruDoctoral School, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Ovidiu Alexandru MederleEmergency Department, Emergency Clinical Municipal Hospital, Timisoara, Romania.
Sergiu BajanDoctoral School, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Brigitha VlaicuDiscipline of Hygiene, Department of Microbiology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Vlad Laurentiu DavidDepartment of Pediatric Surgery and Orthopedics, Louis Turcanu Emergency Children's Hospital, Timisoara, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute appendicitis is the most common pediatric surgical emergency, and a complicated disease associated with greater morbidity and resource use. However, institution-level cost data from Central and Eastern Europe remain limited. This study aimed to quantify the direct hospitalization costs of pediatric acute appendicitis in Western Romania and to assess whether disease severity, postoperative complications, and selected diagnostic or therapeutic factors were associated with higher inpatient costs. We conducted a single-center retrospective study including 1,535 pediatric admissions for acute appendicitis treated surgically between 1 January 2016 and 31 December 2025 at Louis Turcanu Children's Hospital, Timisoara, Romania. Of these, 501 (32.6%) were classified as complicated appendicitis, and 971 (63.3%) patients were male. Median age was 11.08 years (IQR 8.58-14.50). Median length of stay was 6 days (IQR 4-8) overall, but was significantly longer in complicated than in non-complicated appendicitis (8 [7-11] vs. 5 [4-7] days). Median total hospitalization cost was 2,160 RON (IQR 1,406-3,356) overall, increasing from 1,710 RON (IQR 1,187-2,541) in non-complicated cases to 3,364 RON (IQR 2,432-4,618) in complicated cases. Cluster analysis identified four cost profiles; the highest-cost cluster had a median cost of 3,810 RON and the greatest proportion of complicated cases. Admissions with complications also had higher median costs than those without complications (3,441 vs. 1,806 RON) and longer hospitalization (8 vs. 5 days). Complicated pediatric acute appendicitis, therefore, imposes a substantially greater hospitalization burden, with disease severity and length of stay as the principal cost drivers.

Indexed as

AppendicitisHospital CostsHospitalizationAcute DiseaseAdolescentChildFemaleHumansLength of StayMaleRetrospective StudiesRomaniaAA, acute appendicitisacute appendicitisCI, confidence intervalcost analysisCOVID-19, coronavirus disease 2019CT, computed tomographyED, emergency departmentEUR, euroGBD, Global Burden of Diseasehealthcare resource utilizationhospitalization costsICD, International Classification of Diseaseslength of stayLOS, length of stayMRI, magnetic resonance imagingOR, odds ratiopostoperative complicationsRON, Romanian leuSBO, small bowel obstructionUS, ultrasoundZAR, South African rand

Identifiers

PMID42112213
PMCPMC13155160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.