ArticleJournal of ginseng research2026
Alleviating effects of KGC19b on periodontal inflammation through anti-inflammatory and induction of osteogenic differentiation in
Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: HPDL cells were stimulated with PG-LPS for 12 h to evaluate the effects of KGC19b (50-200 μg/mL) on periodontitis. Cell viability, pro-inflammatory markers, reactive oxygen species (ROS), and osteogenesis-related markers were assessed. In the rat model, periodontitis was induced using ligature and PG-LPS, and KGC19b was administered orally for 6 days. The effects of KGC19b were evaluated by micro-CT analysis and H&E staining. Results: KGC19b reduced pro-inflammatory cytokine expression, restored osteogenic markers, enhanced antioxidant enzyme activity, and decreased ROS in HPDL cells. In the rat model, KGC19b alleviated periodontal inflammation and prevented bone mass loss. Conclusion: In this study, KGC19b shows the possibility of improving and treating periodontitis through anti-inflammatory, osteogenesis, and antibacterial effects.
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