Evidence map›Paper›PMID 42112117›Full record

ArticleJournal of ginseng research2026

Protopanaxatriol enhances mucin expression in intestinal epithelial cells and mice.

Yeye Hu, Ziliang He, Weijie Dai, Xuejunlan Hu, Haiyue Hu, Yuhao Wang, Lei Huang, Canglang Mou, Jinghan Su, Weizhaole Wei and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yeye HuDepartment of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Ziliang HeDepartment of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Weijie DaiDepartment of Gastroenterology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, China.
Xuejunlan HuSchool of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Haiyue HuSchool of Basic Medical Sciences, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China.
Yuhao WangDepartment of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Lei HuangDepartment of Biocosmetics, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Canglang MouDepartment of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jinghan SuDepartment of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Weizhaole WeiDepartment of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Haifeng WuInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China.
Long YouDepartment of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Honggang WangDepartment of Gastroenterology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, China.
Jae Youl ChoDepartment of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Weicheng HuSchool of Basic Medical Sciences, Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mucins are critical components of the intestinal mucus layer that protects the gut epithelium and maintains microbiota balance. Protopanaxatriol (PPT), an active metabolite derived from protopanaxatriol-type saponins, has shown promise in modulating gut health, but its effects on mucin expression remain poorly understood. Objective: This study aimed to investigate the effects of PPT on mucin expression in human intestinal epithelial Caco-2 cells and in a mouse model. Methods: Caco-2 cells were treated with different concentrations of PPT, and the expression of mucins was assessed via qRT-PCR and Western blot analysis. In parallel, mice were administered PPT orally, and tissues were collected for mucin quantification. Results: PPT treatment significantly upregulated mucin expression at both the mRNA and protein levels in Caco-2 cells. Conclusion: PPT promoted mucin expression in human intestinal epithelial cells and in the gut of mice, suggesting their potential as natural agents for maintaining gut health and preventing intestinal disorders.

Indexed as

Caco-2 cellsMucinProtopanaxatriol

Identifiers

PMID42112117
PMCPMC13149887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.