Trial reportDrug design, development and therapy2026
Effect of Different Doses of Esketamine on the Propofol Effect-Site Concentration Required to Suppress Cervical Dilation-Associated Movement During Hysteroscopy: A Prospective, Randomised, Controlled, Parallel-Group Dose-Response Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Operative hysteroscopy is commonly performed under propofol-based intravenous anesthesia, but the relatively high propofol requirement needed to suppress movement during cervical dilation may increase the risk of respiratory and hemodynamic adverse events. Esketamine, the active enantiomer of ketamine, has greater analgesic potency and has been increasingly used as a propofol adjunct; however, its dose-dependent effects on propofol effect-site concentration during hysteroscopy remain unclear. Objective: To determine whether esketamine dose-dependently reduces the propofol effect-site concentration required to suppress movement during cervical dilation in operative hysteroscopy. Methods: In this randomised, double-blind, parallel-group dose-response trial, 112 adult women undergoing elective operative hysteroscopy were allocated across five parallel esketamine dose groups (0, 0.1, 0.2, 0.3, or 0.4 mg·kg Results: Esketamine reduced the propofol effect-site EC Conclusion: Esketamine dose-dependently reduced the propofol effect-site concentration required to suppress movement during cervical dilation. In relatively healthy women undergoing short operative hysteroscopy, esketamine 0.2-0.3 mg·kg
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