ReviewReproductive medicine and biology
Dissecting Human Embryogenesis With Blastoids: Insights Into Lineage Specification and Early Development.
Review in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Understanding human embryogenesis is a fundamental goal in developmental biology and reproductive medicine, but direct investigation of human embryos is limited by ethical and technical constraints. Stem cell-based blastocyst models have emerged as alternative systems to recapitulate key features of early human development in vitro. Methods: We reviewed the literature on human stem cell-based embryo models, with a focus on blastoids. Relevant studies and review articles were identified through PubMed, covering blastoid generation strategies, model diversity, and insights into early lineage specification derived from blastoids and pluripotent stem cell studies. Main Findings: Blastoids provide a versatile platform to model key aspects of human blastocyst development, including lineage specification, embryonic-extraembryonic interactions, and early morphogenesis. Recent studies demonstrate their utility in modeling implantation-related processes, embryo-maternal interactions, and responses to genetic, environmental, and pharmacological perturbations. However, current systems remain limited by incomplete lineage representation and restricted capacity to model post-implantation-like development. Ongoing advances in stem cell biology and culture systems are expected to improve their fidelity and developmental potential. Conclusion: Blastoids represent a promising approach for studying early human embryogenesis and are expected to expand their applications in reproductive biology and medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.