ArticleAddictive behaviors reports2026
Altered Resting-State Functional Connectivity in Internet Gaming Disorder: Convergent Evidence and Independent Validation.
Article in Addictive behaviors reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
12 authors.
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Abstract
Background: Internet gaming disorder (IGD) has attracted increasing attention worldwide. However, findings from resting-state functional connectivity (RSFC) studies have remained inconsistent, making it difficult to identify robust and reproducible neural alterations. To address this issue, we performed a coordinate-based synthesis of RSFC studies involving IGD-related conditions and examined whether the principal convergent findings could be replicated in an independent IGD cohort. Methods: Convergent RSFC abnormalities across eligible studies were identified using anisotropic effect size-signed differential mapping (AES-SDM). Clusters derived from the meta-analysis in the middle frontal gyrus and midline medial frontal/cingulate-related region were defined as regions of interest for independent validation. Resting-state fMRI data were collected from 58 individuals with IGD and 38 healthy controls, followed by seed-based RSFC analyses. Group differences were examined using two-sample t-tests with Gaussian random field correction, and brain-behavior associations were evaluated using Pearson correlations. Results: Seventeen studies met the inclusion criteria for meta-analysis. Convergent RSFC abnormalities were mainly observed in the median cingulate/paracingulate region and bilateral middle frontal gyrus. In the independent sample, individuals with IGD showed significant seed-based RSFC alterations involving both the middle frontal gyrus seed and the midline medial frontal/cingulate-related seed. Connectivity strength related to the middle frontal gyrus seed was positively associated with Internet Addiction Test scores. Conclusions: These findings provide convergent evidence for abnormal resting-state connectivity in IGD, particularly in frontal and midline regions involved in executive control and self-referential processing. Independent validation further supports the reproducibility and potential clinical relevance of these regionally specific alterations.
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