ArticleFrontiers in nutrition2026
Novel prediction equations for appendicular skeletal muscle mass in hemodialysis patients: referenced against bioelectrical impedance analysis.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Toward Clinically Feasible Assessment of Muscle Mass: Validation of a Seated Bioelectrical Impedance Device Against Dual-Energy X-Ray Absorptiometry (DXA) in Older Adults.Sensors (Basel, Switzerland) · 2026Article
- Diagnostic performance of ultrasonographic medial gastrocnemius muscle thickness for sarcopenia in patients on maintenance hemodialysis.Frontiers in medicine · 2026Article
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Authors and funding
13 authors.
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Abstract
Background: Accurate assessment of appendicular skeletal muscle mass (ASM) is essential in clinical practice and research involving patients undergoing hemodialysis (HD). However, ASM prediction equations developed in the general population may be inappropriate for HD patients because of dialysis-related alterations in body composition and hydration status. Objective: To evaluate the performance of existing anthropometric ASM prediction equations in HD patients and to develop dialysis-specific equations tailored to this population. Methods: In this cross-sectional study, 111 patients receiving maintenance hemodialysis were enrolled. ASM was measured using multi-frequency bioelectrical impedance analysis (BIA) under standardized post-dialysis conditions. The performance of three previously published equations, namely the height-weight (HW), limb-length-circumference (LC), and height-circumference (HC) models, was assessed. New dialysis-specific equations were developed using anthropometric variables through linear regression. Agreement was evaluated using Bland-Altman analysis, and internal validation was performed using cross-validation and bootstrap resampling. Results: Existing equations demonstrated limited agreement with BIA-measured ASM, showing substantial systematic bias and wide limits of agreement. Two dialysis-specific equations were developed: an advanced HW model (adjusted R Conclusion: ASM prediction equations derived from the general population have limited applicability in patients undergoing maintenance hemodialysis. Dialysis-specific anthropometric calibration improves agreement with reference ASM, with the HH equation providing a practical and reliable tool for muscle mass assessment in this population.
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