Evidence map›Paper›PMID 42111821›Full record

ArticlePeerJ2026

A retrospective quantitative CT study reveals subclinical pulmonary vascular loss and right middle lobe vulnerability in PM/DM patients without interstitial lung disease.

He Hei, Kai Yang, Liyu He, Guoqing Sun, Guohua Xia, Shuo Yu, YuTing Zhang, Jiayin Tong, Jingping Zhang, Yanrong Chen and 1 more

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Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

He HeiDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Kai YangDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Liyu HeDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Guoqing SunDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Guohua XiaDepartment of Otorhinolaryngology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Shuo YuSchool of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China.
YuTing ZhangDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Jiayin TongDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Jingping ZhangDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Yanrong ChenDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Chenwang JinDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Connective tissue disease-associated interstitial lung disease (CTD-ILD) is triggered by pulmonary vascular injury. However, early subclinical lung changes in polymyositis/dermatomyositis (PM/DM) patients without ILD (PM/DM-non-ILD) remain undetectable by conventional imaging. Objective: To evaluate microvascular integrity and parenchymal features in PM/DM-non-ILD patients using quantitative computed tomography (QCT). Additionally, this study aims to identify associations between QCT parameters and laboratory markers of inflammation and autoimmunity, and evaluate the performance of QCT metrics in detecting subclinical lung pathology. Method: This retrospective study included 71 PM/DM-non-ILD patients and 71 age- and sex-matched healthy controls were enrolled. Chest high-resolution CT (HRCT) images, laboratory data, and clinical records were collected. All HRCT scans were analyzed using the "Digital Lung" platform to obtain QCT parameters, including lung volume, density, and intrapulmonary vascular volumes (IPVV) for the whole lung and individual lobes. Standardized IPVV was calculated by dividing the vascular volume by the corresponding lobe volume to account for lung volume differences. QCT parameters and laboratory results were compared, their correlation analyzed, and diagnostic performance evaluated using receiver operating characteristic (ROC) analysis. Results: In PM/DM-non-ILD patients, standardized IPVV was notably lower in the entire lung and each lobe compared to healthy controls ( Conclusion: The decreased standardized intrapulmonary vascular volume (IPVV), across all lung lobes (whole lung, right lung, left lung, right upper lobe, right middle lobe, right lower lobe, left upper lobe, left lower lobe) indicates its potential as a sensitive marker for early pulmonary involvement in patients with polymyositis/dermatomyositis without interstitial lung disease. The distinct vascular changes in the right middle lung lobe may serve as a discriminative indicator for subclinical lung pathology in this population, potentially reflecting underlying immune dysregulation.

Indexed as

DermatomyositisLungPolymyositisTomography, X-Ray ComputedAdultAgedCase-Control StudiesFemaleHumansLung Diseases, InterstitialMaleMiddle AgedRetrospective StudiesNon-interstitial lung diseasesPolymyositis/dermatomyositisPulmonary vascular volumeQuantitative CT

Identifiers

PMID42111821
PMCPMC13151928

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.