ArticlePeerJ2026
Natural scopoletin isolated from rubiaceous plants: a precursor for the synthesis of benzoylscopoletin and its cytotoxicity.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Scopoletin, a compound abundant in Rubiaceae such as Materials and Methods: Stem bark of Results: The lipophilic extracts displayed scopoletin contents of 16.14% and 13.94%, respectively. Scopoletin was completely converted to a target derivative, 6-methoxy-2-oxo-4a,8a-dihydro-2H-chromen-7-yl benzoate. This compound exhibited an IC Conclusions: We completely actualized both isolation and synthesis to achieve a high yield of the target scopoletin and benzoylscopoletin. The cytotoxicity evidence obtained from this study supports the establishment of safe dosage limits, which have not been previously reported. This finding provides a scientific basis for further drug development. The analyses demonstrate reproducible isolation of scopoletin and synthesis of the derivative.
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