Evidence map›Paper›PMID 42111760›Full record

ArticleMaterials today. Bio2026

Injectable and viscoelastic click alginate hydrogels for spatio-temporal T cell administration in vivo.

Jone Berasain, Sara Manzano, Oihane Mitxelena-Iribarren, Unai Heras, Ainhoa Romo-Valera, Peio Azcoaga, Leire Iturriaga, Leire Egia-Mendikute, Asís Palazón, Mercedes Fernández and 3 more

Abstract read
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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jone BerasainGroup of Bioengineering in Regeneration and Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.
Sara ManzanoGroup of Breast Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.
Oihane Mitxelena-IribarrenGroup of Bioengineering in Regeneration and Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.
Unai HerasGroup of Bioengineering in Regeneration and Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.
Ainhoa Romo-ValeraGroup of Breast Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.
Peio AzcoagaGroup of Breast Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.
Leire IturriagaGroup of Bioengineering in Regeneration and Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.
Leire Egia-MendikuteCancer Immunology and Immunotherapy Laboratory, CIC bioGUNE-BRTA, Derio, Spain.
Asís PalazónCancer Immunology and Immunotherapy Laboratory, CIC bioGUNE-BRTA, Derio, Spain.
Mercedes FernándezPOLYMAT, University of the Basque Country EHU, San Sebastian, Spain.
María M CaffarelGroup of Breast Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.
Robert AguirresarobeDepartment of Advanced Polymers and Materials: Physics, Chemistry and Technology, Faculty of Chemistry, University of the Basque Country EHU, San Sebastian, Spain.
Amaia CipitriaGroup of Bioengineering in Regeneration and Cancer, Biogipuzkoa Health Research Institute, San Sebastian, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cell therapies have shown limited success in solid tumors, mainly due to the difficulty of T cells to penetrate the tumor tissue. Here, we develop injectable and viscoelastic click alginate hydrogels for local and sustained delivery of T cells, with the goal to improve T cell administration, viability, proliferation, and persistence

Indexed as

Chick chorioallantoic membrane (CAM) modelInjectable hydrogelIn vivo mouse modelT cell deliveryViscoelasticity

Identifiers

PMID42111760
PMCPMC13156761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.