ReviewJournal of nutrition and metabolism2026
Fructose Diet-Induced Liver Injury Through Oxidative Stress: A Systematic Review of Preclinical Studies.
Review in Journal of nutrition and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Fructose Diet-Induced Liver Injury Through Oxidative Stress: A Systematic Review of Preclinical Studies.Journal of nutrition and metabolism · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fructose consumption has significantly increased in recent years and is associated with hepatic oxidative stress, playing a major role in metabolic diseases such as metabolic-associated fatty liver disease (MAFLD). This systematic review aimed to summarize how excessive fructose consumption causes liver injury through oxidative stress, leading to lipid accumulation in hepatic cells. Methods: PubMed, Scopus, and Web of Science databases were systematically searched (2019-2024) for preclinical studies using fructose-only diets. Criteria were applied to identify relevant studies. The primary outcome was hepatic oxidative stress, and the secondary outcomes included weight, metabolic markers, liver function, and histopathology changes. Two reviewers assessed bias risk using SYRCLE. Results: Among 517 studies screened, 26 met the inclusion criteria. Most studies had unclear bias risk due to poor reporting. Low-dose fructose intake (10%) over 8-12 weeks induced hepatic oxidative stress, indicated by elevated malondialdehyde (MDA) in 53.8% of cases, increased reactive oxygen species (ROS) in 19.2%, and reduced antioxidant defenses, including glutathione (GSH), GSH peroxidase (GSH-Px), and superoxide dismutase (SOD) in 38.5%. Four studies showed early upregulation of antioxidant responses (11.5%), suggesting initial adaptation. Prolonged fructose exposure (up to 36 weeks) caused sustained liver injury due to overwhelming defenses and increased oxidative stress. Most studies also reported metabolic disturbances, liver dysfunction, and lipid accumulation. Conclusion: This systematic review showed that excessive fructose consumption induces liver injury through oxidative stress, which then triggers subsequent processes like inflammation. Overconsumption led to uncontrolled hepatic metabolism, increasing lipid synthesis, metabolic overload, overproduction of ROS, impairment of antioxidant defenses, and histopathological changes.
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Registered trials
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