Evidence map›Paper›PMID 42111655›Full record

ArticleGlomerular diseases

Serum Phospholipase A2 Receptor Antibody Is Associated with Thrombogenesis in Primary Membranous Nephropathy: A Systematic Review and Meta-Analysis.

Paula Dibo, Henrique Alexsander Ferreira Neves, Raghunandan Konda, Alanis Yael Szyferman, Federico Napoli, Ifunanya Peculiar Nnajiofor, Clara Campoverde, Saeed Razaq, Arun Rajasekaran

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Article in Glomerular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Paula DiboDivision of General Internal Medicine, Department of Medicine, Emory University, AtlantaGA, USA.
Henrique Alexsander Ferreira NevesFederal University of Paraná, Curitiba, Brazil.
Raghunandan KondaDivision of Nephrology, University of Alabama at Birmingham, BirminghamAL, USA.
Alanis Yael SzyfermanUniversidad Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Federico NapoliDivision of Internal Medicine, San Giuseppe Hospital, IRCCS MultiMedica, Milan, Italy.
Ifunanya Peculiar NnajioforBasingstoke and North Hampshire Hospital, Basingstoke, UK.
Clara CampoverdeUniversidad de Cuenca, Cuenca, Ecuador.
Saeed RazaqDivision of Nephrology, University of Alabama at Birmingham, BirminghamAL, USA.
Arun RajasekaranGlomerular Disease Kidney Center, Renal Medicine Associates, Albuquerque, NM, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Primary membranous nephropathy (PMN) is a leading cause of nephrotic syndrome in adults and is associated with an increased risk of thromboembolic events. The anti-serum phospholipase A2 receptor antibody (anti-PLA2R Ab) is highly specific for PMN, correlates with immunological disease activity, and evidence suggests that it may contribute to a prothrombotic state. This systematic review and meta-analysis aimed to further explore the potential association between serum anti-PLA2R Ab and thromboembolic events in patients with PMN and investigate whether they may serve as a possible biomarker for thrombogenesis. Methods: PubMed, Embase, and Cochrane databases were systematically searched for studies that investigated the presence of anti-PLA2R Ab as a potential risk factor for thrombogenesis in patients with PMN. Odds ratios (ORs) and mean differences with 95% confidence intervals (CIs) were pooled across studies. Heterogeneity was evaluated using I Results: We included seven studies involving 1,162 patients; mean age was 53 years. Patients with anti-PLA2R Ab had significantly higher odds of thromboembolism compared to those without anti-PLA2R Ab (OR 1.52; 95% CI 1.10, 2.09; Conclusion: There was a significant association between the presence of anti-PLA2R Ab and the risk of thromboembolism in patients with PMN, supporting their potential use as a biomarker for thrombogenesis in this population.

Indexed as

CreatinineGlomerular filtration ratePrimary membranous nephropathyProteinuriaSerum albuminSerum phospholipase A2 receptor antibodiesThromboembolismThrombogenesisTotal cholesterol

Identifiers

PMID42111655
PMCPMC13152271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.