ArticleERJ open research2026
Diagnostic yield and histopathological assessment of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy: a prospective comparison of two tunnelling approaches.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- Transbronchial Mediastinal Cryobiopsy-Rising to the Challenge.Respirology (Carlton, Vic.) · 2026Article
- Cryobiopsy Outperforms Fine-Needle Aspiration for Mediastinal Lymphadenopathy: A Within-Patient Diagnostic Accuracy Study and Clinical Predictors of Success.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used for mediastinal and hilar lymph node evaluation, although its diagnostic performance may be limited in rare tumours, benign diseases, lymphoproliferative disorders and for detailed molecular analyses. Data on the role of EBUS-guided transbronchial mediastinal cryobiopsy (EBUS-TMC) remain limited. Methods: We conducted a prospective cohort study in 90 patients undergoing EBUS-TBNA and EBUS-TMC for mediastinal or peribronchial lesions ≥1 cm. Two tunnelling approaches using 22-G (SonoTip TopGain) and 19-G (ViziShot 2 FLEX) TBNA needles were employed. TBNA and cryobiopsy with a 1.1-mm cryoprobe were performed sequentially in the same lymph node. Results: 45 patients were assigned to each group. The diagnostic yield of EBUS-TMC was 91.1% (22-G) and 93.3% (19-G) (p=0.0005 and p=0.006, respectively, Conclusions: EBUS-TMC is a safe, feasible and minimally invasive method with superior diagnostic yield and histological quality compared to EBUS-TBNA. Both 22-G and 19-G approaches are effective; 22-G is more adaptable for distal targets, while 19-G is suited for centrally located or accessible lesions. Combining EBUS-TBNA and EBUS-TMC may further enhance diagnostic accuracy in complex cases.
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Registered trials
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