Bronchoscopic Cryodebulking and Airway Stenting for Endobronchial Metastasising Ameloblastoma: A Case Report.

Metastasising ameloblastoma (MA) is a rare odontogenic tumour with an unpredictable natural history, capable of presenting decades after primary resection. Pulmonary involvement is the most common site of distant spread; however, endobronchial disease-causing airway obstruction and haemoptysis is exceptionally rare, with very few cases reported in the literature. Existing reports describe modest and short-lived responses to endobronchial therapy, with rapid recurrence. We report a case of bilateral endobronchial MA presenting 31 years after mandibular resection, where surgical intervention was not feasible and systemic therapy was declined by the patient. A multimodal bronchoscopic approach combining bronchial artery embolization, cryodebulking, and airway stenting achieved sustained airway patency and symptom control, with no tumour ingrowth at nearly 1 year. This case challenges the perception that endobronchial MA carries a uniformly poor bronchoscopic response and demonstrates that interventional pulmonology techniques can offer meaningful and durable palliation in this rare condition.