ArticleDose-response : a publication of International Hormesis Society
Heterogeneous Biological Responses to Low-Level Sodium Saccharin Exposure: An Integrated Computational Toxicology and Mendelian Randomization Study.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The long-term biological effects of low-level exposure to artificial sweeteners remain debated. We integrated computational toxicology and Mendelian randomization (MR) to explore potential biological responses associated with sodium saccharin across multiple cancer outcomes. Methods: Public databases were screened to identify saccharin-related targets, followed by protein-protein interaction network construction and enrichment analyses. Molecular docking assessed binding potential. Two-sample MR analyses were conducted using European genome-wide association study (GWAS) summary statistics to evaluate potential causal associations. Results: Among 191 identified targets, 160 overlapped with genes implicated across 36 cancer types. Hub genes included Conclusion: Sodium saccharin may interact with cancer-related molecular networks; however, population-level evidence indicates heterogeneous and context-dependent associations rather than a generalized carcinogenic effect under low-level exposure conditions.
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