Evidence map›Paper›PMID 42111479›Full record

ArticleInternational journal of particle therapy2026

Characterization of a Low-Energy Cyclotron-Based Proton Beam for Preclinical Radiobiological Studies.

Ana Rita C Teixeira, Sérgio J C Do Carmo, Sofia Silva, Catarina I G Pinto, Pedro Santos, Paulo Crespo, Joana Lencart, António Paulo, Célia M Gomes, Antero J Abrunhosa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of particle therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ana Rita C TeixeiraICNAS/CIBIT - Institute for Nuclear Sciences Applied to Health/Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Pólo das Ciências da Saúde, Coimbra, Portugal.
Sérgio J C Do CarmoICNAS/CIBIT - Institute for Nuclear Sciences Applied to Health/Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Pólo das Ciências da Saúde, Coimbra, Portugal.
Sofia SilvaMedical Physics, Radiobiology and Radiation Protection Group, Research Center of IPO Porto (CI-IPOP), IPO-Porto, Porto, Portugal.
Catarina I G PintoCentro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Lisboa, Portugal.
Pedro SantosCentro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Lisboa, Portugal.
Paulo CrespoLIP - Laboratório de Instrumentação e Física Experimental de Partículas, Coimbra, Portugal.
Joana LencartMedical Physics, Radiobiology and Radiation Protection Group, Research Center of IPO Porto (CI-IPOP), IPO-Porto, Porto, Portugal.
António PauloCentro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Lisboa, Portugal.
Célia M GomesiCBR - Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Antero J AbrunhosaICNAS/CIBIT - Institute for Nuclear Sciences Applied to Health/Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Pólo das Ciências da Saúde, Coimbra, Portugal.
Filipa MendesCentro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Lisboa, Portugal.
Francisco AlvesICNAS/CIBIT - Institute for Nuclear Sciences Applied to Health/Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Pólo das Ciências da Saúde, Coimbra, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Proton therapy is considered an attractive alternative to conventional radiotherapy in oncology, as its dose-depth curve favors tumor control while minimizing the risk of radiation-induced side effects in healthy tissue. Preclinical investigation into proton Relative Biological Effectiveness (RBE) is imperative to improve the current clinical RBE standard and subsequently optimize therapeutic efficacy. Materials and Methods: A low-energy cyclotron-based proton irradiation set-up for Results: Homogeneous dose profiles were achieved on a 21 mm-diameter circular area at the target region for an incident proton energy of 14 MeV. A linear relation was found between proton dose at the target and integrated beam charge for pulsed dose rates from 10.8 to 16.2 Gy/s and a proton flux of ∼ 10 Conclusion: A cyclotron-based pulsed proton beam was successfully optimized for

Indexed as

in vitro researchPulsed proton beamRadiobiologyRadiochromic film dosimetryRelative Biological Effectiveness (RBE)

Identifiers

PMID42111479
PMCPMC13156708

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.