ArticleJournal of diabetes and metabolic disorders2026
Genetic predisposition to diabetes and risk of stroke in a Native Hawaiian population.
Article in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Diabetes is a highly heritable risk factor for stroke, with many known genetic variants. The role of these genetic variants in cerebrovascular disease has not been studied in Kānaka Maoli (Native Hawaiian) populations. We aimed to determine if genetic predisposition to diabetes is associated with a higher risk of stroke in a Kānaka Maoli population. Methods: We conducted a genetic association case/control study using data from Kānaka Maoli participants in the Population Architecture using Genomics and Epidemiology (PAGE) study. Stroke cases were identified through health questionnaires and matched by age and sex at a 1:10 ratio. We modeled genetic predisposition to diabetes with a polygenic risk score that included independent genetic variants known to be associated with diabetes at a genome-wide significance level ( Results: A total of 440 Kānaka Maoli individuals were included (15% under 50 years old, 85% aged 50-69, 65% female). There were 40 stroke patients and 400 age- and sex-matched control subjects. Genetic predisposition to diabetes was linked to a 23% increased risk of developing diabetes (OR 1.23, CI 1.01-1.51; Conclusions: In a Kānaka Maoli population, genetic predisposition to diabetes is associated with an increased risk of stroke. Future research to identify effect modifiers of this relationship may uncover significant public health strategies.
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