Evidence map›Paper›PMID 42111401›Full record

ArticleJHLT open2026

Reversal of lung consolidation with mechanical insufflation-exsufflation in a brain-dead lung donor.

Silmary Maichle, Inés García-González, Manuel Solís-Jara, Viktor Yordanov-Zlatkov, Patricia Alonso-Martínez, María Vidal-Martínez, Francisco Del-Río-Gallego, Miguel Sánchez-García

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Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Silmary MaichleDepartment of Critical Care, Hospital Clínico San Carlos Madrid, Madrid, Spain.
Inés García-GonzálezDepartment of Critical Care, Hospital Clínico San Carlos Madrid, Madrid, Spain.
Manuel Solís-JaraDepartment of Critical Care, Hospital Clínico San Carlos Madrid, Madrid, Spain.
Viktor Yordanov-ZlatkovDepartment of Critical Care, Hospital Clínico San Carlos Madrid, Madrid, Spain.
Patricia Alonso-MartínezDepartment of Critical Care, Hospital Clínico San Carlos Madrid, Madrid, Spain.
María Vidal-MartínezDepartment of Radiology, Hospital Clínico San Carlos, Madrid, Spain.
Francisco Del-Río-GallegoOffice for Regional Transplant Coordination, Servicio Madrileño de Salud, Madrid, Spain.
Miguel Sánchez-GarcíaDepartment of Critical Care, Hospital Clínico San Carlos Madrid, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shortage of donor lungs for transplantation is largely a consequence of low utilization rates and long waitlists persist despite growth of transplant activities. Low utilization frequently reflects early respiratory complications. We describe a brain-dead potential donor with lung infiltrates and relative hypoxemia, in whom lung suitability for transplantation was restored after airway clearance with mechanical insufflation-exsufflation (MI-E), combined with nebulized hypertonic saline (HS). To our knowledge, this is the first description of effective non-invasive recovery of donor lungs through active secretion mobilization. The low-cost uncomplicated combination of interventions warrants prospective evaluation for inclusion in donor-management protocols.

Indexed as

Airway clearanceAspiration pneumoniaLung donorMechanical insufflation-exsufflationNebulized hypertonic saline

Identifiers

PMID42111401
PMCPMC13157040

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.