ArticleERJ open research2026
Clinical impact and healthcare resource utilisation in patients with unexplained or refractory chronic cough: a French national population study.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background: The epidemiological, clinical and medico-economic burden of unexplained or refractory chronic cough (URCC) is poorly known. Objective: To describe sociodemographic characteristics, clinical impact, healthcare resource utilisation and associated costs in French patients with URCC. Methods: Populations of interest (chronic cough, URCC, controls) were identified from the general population-based Constances cohort (124 565 participants at the time of study inception) and invited to answer a specific Results: Populations of interest were identified among participants for whom data and questionnaire responses were available (n=5277): URCC (n=116), non-URCC (n=1357) and no chronic cough (reference group; n=3804). The extrapolated frequencies of chronic cough and URCC in the Constances cohort were 3.8% and 0.22%, respectively. URCC was mainly associated with gastro-oesophageal reflux disease (31.0%) and asthma/COPD (18.3%). Depressive symptoms (Center for Epidemiological Studies Depression scale score ≥16) were significantly more frequent in patients with URCC than in controls (43.0% Conclusions: URCC is associated with an important clinical impact and high healthcare resource utilisation and associated costs. The burden of URCC is significant and remains an unmet medical need.
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