Evidence map›Paper›PMID 42111372›Full record

ArticleERJ open research2026

Small airways disease is common in mild COPD and symptomatic subjects at risk with normal spirometry: baseline data from CAPTO-COPD.

Frederik Trinkmann, Mustafa Abdo, Felix J F Herth, Klaus F Rabe, Anne-Marie Kirsten, Henrik Watz

Abstract read
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Frederik TrinkmannDepartment of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Translational Lung Research Center Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany.ORCID https://orcid.org/0000-0001-5877-877X
Mustafa AbdoLungenClinic Grosshansdorf, Airway Research Center North (ARCN), DZL, Grosshansdorf, Germany.
Felix J F HerthDepartment of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Translational Lung Research Center Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany.ORCID https://orcid.org/0000-0002-7638-2506
Klaus F RabeLungenClinic Grosshansdorf, Airway Research Center North (ARCN), DZL, Grosshansdorf, Germany.
Anne-Marie KirstenPulmonary Research Institute at the LungenClinic Grosshansdorf, ARCN, DZL, Grosshansdorf, Germany.
Henrik WatzPulmonary Research Institute at the LungenClinic Grosshansdorf, ARCN, DZL, Grosshansdorf, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Current guideline-based diagnosis of airflow limitation in COPD focuses on spirometry, which is insensitive to early small airway changes of symptomatic smokers or subjects at risk. Therefore, we sought to determine the frequency of small airways disease (SAD) in these groups compared with mild COPD, and evaluate associations with symptoms as well as health-related quality of life (HRQoL). Methods: Patients with mild COPD (post-bronchodilator forced expiratory volume in 1 s (FEV Results: We present cross-sectional baseline data from 90 COPD patients (mean±sd age 65±9 years; mean±sd FEV Conclusion: SAD is common even in symptomatic (ex-)smokers not fulfilling spirometric criteria with a similar frequency and pattern as compared to mild COPD patients. SAD is associated with impaired HRQoL, even in patients without established COPD.

Identifiers

PMID42111372
PMCPMC13152375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.